This study is a ten year retrospective study of histopathological pattern of prostatic lesions as seen at Jos University Teaching Hospital (JUTH) Jos over a ten year period between January 2000 and December 2009. A total of 22,952 surgical specimens were received in JUTH histopathology department within the study period out of which 1,450(6.3%) were prostatic specimens made up largely of trucut biopsies and prostatectomy specimens and all specimens were from black men. Majority of the lesions (1,029 or 70.9%) were cases of Nodular Hyperplasia (NH). High Grade Prostatic Intraepithelial Neoplasia lesion (HGPIN) with its associated lesions constituted 41(2.8%) while 377 (26%) turned out to be Cancer of the Prostate (CAP). The ratio of NH to CAP in this study was 2.73:1. Also three cases (0.2%) were strictly chronic prostatitis. NH with a predominant glandulostromal pattern constituted 87.9% while a predominant stromal pattern was recorded in 12.1%. The commonest histopathological pattern of CAP was adenocarcinoma (96%) with most (67.7%) of them being well differentiated. The paucity of other histological patterns was also noted with the commonest amongst them in this study being Transitional cell carcinomas (9 or 2.4%) out of which seven were metastatic. Furthermore Gleason grade pattern “3” was mostly observed in the adenocarcinomas representing 36.9% where-as combined Gleason grade or Gleason score of “4” (35.4%) was the 1 most frequent in this study. Also noteworthy is that while most of the NH and CAP lesions were seen in the 7th decade, most of the HGPIN lesions were observed in the 8th decade. This study recorded frequency of one CAP lesion in every six male malignancies i.e. 16.7% of the total 2,262 malignant male lesions and also 47% of the total 783 malignant male urological lesions diagnosed in JUTH which re affirms that the lesion is commoner than previously assumed and that it still remains the commonest male malignancy in North Central Nigeria. Likewise this study further supports the observed upward trend in the incidence of CAP in many regions of Nigeria. This apparent increase may be due to some factors like expanding population, adoption of westernized type of diet e.g. animal proteins, animal fats & calorie, greater public awareness of prostatic diseases, better equipped and established urological units in many more tertiary institutions and availability of improved screening cum diagnostic procedures. Also with only few exceptions, the pattern of prostatic lesions in this study compare favourably with the previous similar study in this centre and to most findings within Nigeria, Africa and globally. Having embarked on this study, it is highly recommended that Trans Rectal Ultra Sound (TRUS) guided sextant biopsy, its modifications, Trans Urethral Resection of the Prostate (TURP) and more specific modifications of PSA measurements should be routine procedures in our tertiary institutions. It is also recommended that there should be more collaboration between the histopathologist, urologist, radiologist and radiotherapist in various aspects of prostatic diseases for the common good of the patients. Finally it is hoped that this study will provide a useful platform upon which future research questions into areas not dealt with in this study will be answered.