INTRODUCTION: Worldwide, prostate cancer is the sixth most common cancer in the world with African Americans having higher incidence. Europeans are known to have intermediate rate while it is said to be rare in Asian populations. Recent studies have not agreed with earlier reports which showed prostatic cancer to be rare in Africans. Histopathologically, adenocarcinomas appear to be the predominant sub-type. The Gleason grading which was named after Donald F Gleason, is still the predominant grading system recommended by the consensus conference in 1993. The application of cancer over expressed biomarkers such as AMACAR is used in conjunction with basal cell markers such as p63, 34βE12, CK5/6 , in making definitive diagnosis of prostate cancers when confronted with difficult cases. Objective The study was aimed at documenting the histopathological patterns, frequency rate and age distribution of prostate cancers in a newly established Tertiary Health Care Centre institution over a seven (7) year period. Materials and Method The materials were mainly Paraffin embedded tissue blocks, histology report forms of all prostate biopsies received in the Histopathology laboratory of the Federal Medical Centre Keffi from January 2007 to December 2013 and records from the hospital cancer registry. Tissue blocks were sectioned into 5µm sections, stained with standard Haematoxylin and Eosin at the histopathology laboratory of the Jos University Teaching Hospital, while inconclusive cases were immunostained with p63 and AMACAR at the National Hospital Abuja, Pathology Department.