BACKGROUND Nasopharyngeal cancer (NPC) is a rare cancer worldwide. It is now found to be increasing in incidence in Nigeria, though the incidence is lower when compared to countries in the Mediterranean basin, North Africa and Southeast Asia. NPC is frequently associated with Epstein-Barr virus (EBV), but no previous study was done in this centre to document the association OBJECTIVES To determine the prevalence, histologic types and age distribution of nasopharyngeal malignancy in Lagos University Teaching Hospital (LUTH) and its association with Epstein-Barr virus (EBVld) over a period of 10 years, between January 2003 to December 2012 MATERIALS AND METHODS The materials for this study consisted of paraffin embedded tissue blocks, hospital request forms, patients case notes and duplicate copies of histopathology reports of cases of histologically-diagnosed nasopharyngeal cancer at Anatomic and Molecular Pathology Department of Lagos University Teaching Hospital (LUTH) between January 2003 and December 2012. The cancer was reclassified into epithelial and non-epithelial malignancy. Under the epithelial malignancy, is the nasopharyngeal carcinoma which is reclassified in accordance with World Health Organisation (WHO) classification. Immunohistochemistry (IHC) for EBV latent membrane protein-1 (LMP-1) were also done to evaluate the prevalence of Ebv in nasopharyngeal malignancy