Background: Glaucoma is the leading cause of irreversible blindness among adults in the world.1 It is a chronic disease that can impact negatively on a patient’s quality of life and vision related functioning. Quality of life is a useful tool in understanding the progression of glaucoma and better management of the glaucoma patient.1 Several coping styles are adopted by glaucoma patients in an attempt to cope with the poor quality of life that comes with the disease. Objective: The major objective of this study was to investigate the vision-related quality of life and coping strategies of glaucoma patients at a secondary eye care unit. Methods: The quality of life of one hundred and thirty consenting adult glaucoma patients aged 18 years and above who were being treated for glaucoma in the Cross River State Eye Care Programme clinic in Calabar was assessed using two quality of life instruments. Coping styles were investigated by means of the 28-item Brief-COPE inventory in this descriptive cross sectional study.