Background: Thrombotic complications are the leading cause of mortality in Diabetes Mellitus (DM), accounting for 80% of DM related deaths. This is due to the fact that DM has been described as a hypercoagulable state with reduced fibrinolysis. Haemostatic parameters of diabetics worldwide have showed different results when studied. With an increase in the global and local prevalence of Type 2 Diabetes Mellitus (T2DM), it was deemed necessary to study some haemostatic parameters of T2DM patients in Akwa Ibom, South South Nigeria to see if these parameters could predict the risk for thrombosis in group studied. Methods: The study conducted in University of Uyo Teaching Hospital, Uyo, was an observational cross-sectional study that examined some haemostatic profiles of some T2DM patients who attended the Diabetic Clinic of our hospital. Forty-four subjects and forty-four controls who met the inclusion criteria were recruited after informed, understood consent was obtained. Data on sociodemographic information, history and physical findings were obtained using interviewer based questionnaires. Relevant laboratory investigations which included full blood count (FBC) by standard methods, Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT), plasma Protein C 2 concentration was determined using ELISA kit from AssayPro USA and glycated haemoglobin with Clover AIc self catridges and analyser from Infopia, Korea.