BACKGROUND: Diabetes mellitus (DM) is a chronic metabolic disorder with predisposition to thrombus formation. There are limited data available on the haemostatic parameters of DM in this environment. AIMS AND OBJECTIVES: This study is aimed at describing the haemostatic parameters in patients with diabetes mellitus in this centre. It also sought to determine any relationship between haemostatic parameters and factors associated with DM as well as the relationship between haemostatic parameters and fasting blood glucose levels in DM. METHOD: Fifty persons with DM in the endocrinology clinic were enrolled in the study using convenience sampling. Fifty age and sex matched non diabetic controls were also enrolled in the study from the family medicine clinic. Clinical parameters (age, blood pressure, body mass index and the duration of disease) were obtained. Samples of blood were collected for Full Blood Count (FBC), determination of haemostatic parameters and biochemical assays. The FBC, Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT), Thrombin Time (TT) and Fibrinogen Weight were determined in the Haematology laboratory. Fasting blood glucose was determined using a glucometer while Urea, Creatinine and Lipids were measured in the chemical pathology laboratory of the hospital. RESULTS: The differences in systolic blood pressure, diastolic blood pressure and body mass index were statistically significant between the diabetic and control groups (P < 0.05). Haemostatic parameters in persons with diabetes mellitus were not deranged, but there were statistically significant differences in the PT, APTT, TT and Fibrinogen weight between the diabetic subjects and the controls (P < 0.05). There were also statistically significant differences between total White Blood Cell count, Platelet count, Erythrocyte Sedimentation Rate, serum Creatinine and Lipids between the two groups (P<0.05) though all values were within normal limits. The difference in Urea level was not statistically significant (P > 0.05). There were weakly positive or no correlation between the haemostatic parameters and factors associated with DM in persons with diabetes mellitus (r < 0.50, P>0.05). The correlations between the fasting blood glucose of persons with diabetes mellitus and PT, APTT and Fibrinogen weight were weakly positive (r < 0.50, P>0.05). Several factors associated with DM however related significantly with haemostatic parameters when analysed in persons with uncontrolled Diabetes mellitus. CONCLUSION: In this study, haemostatic parameters in persons with DM are significantly prolonged than the control values though within normal range. The haemostatic parameters have little or no correlation with factors associated with diabetes mellitus such as blood pressure, body mass index, age, serum lipids, total WBC, Platelet count and duration of the disease. This study also showed that uncontrolled glycaemia may enhance relationship between factors associated with DM and haemostatic parameters. RECOMMENDATION: Further studies on haemostasis such as factor assay in diabetes mellitus are recommended to generate local data that may assist in the management of persons with the disease in our setting.