ABOUT BOOK

Lynch syndrome (LS) (MIM No. 120435-6), previously known as hereditary nonpolyposis colorectal cancer (HNPCC) (Boland, 2005), is an autosomal dominant disorder caused by ~ ~germline mutation in one of the DNA mismatch repair (MMR) genes. LS is among the most ~ ~prevalent cancer syndromes in man and is estimated to account for 1-6% of all colorectal ~ ~cancers (Lynch & de la Chapelle, 2003).