Aim: To determine the pattern of follow-up adherence and the predictors associated with poor follow-up among glaucoma patients in Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, with a view to improving their glaucoma management. Methodology: This was a descriptive comparative cross-sectional study conducted on 125 eligible consenting adults aged 18years and above with glaucoma who presented at the general and subspecialty out-patient eye clinics. They were recruited consecutively into a Poor follow-up group and Good follow-up group, based on the percentage of scheduled appointments in which patients attended in a year. Patients who did not attend up to 75% of scheduled appointments over one year were considered to have poor follow-up and those that attended at least 75% of scheduled clinic visits were considered to have good follow-up. Diagnosis and severity of glaucoma was based on clinical features and visual field test results. Data analysis was done using IBM Statistical Package for Social Sciences (IBM SPSS, Inc., Chicago, Illinois, USA) for Windows version 20.0. A chi square test was used to examine the relationship between follow-up and other variables. Simple linear regression analysis was used to identify the predictors of poor follow-up to glaucoma clinic visits. A multiple logistic regression analysis was used to determine the relationship between various factors that can determine follow-up adherence among patients. The significance level was set at (p<0.05) in all tests.