Introduction: Endometrial cancer is the seventh most common cancer in women globally. Studies from Nigeria have put it behind cervical and ovarian cancer in terms of incidence. Endometrial cancer’s incidence is increasing globally with increased prevalence of obesity and metabolic syndrome. Dyslipidaemia, a component of the metabolic syndrome has been associated with endometrial cancer especially among Caucasians, however little is known about this relationship in Africans. Aim: This study aimed to describe the pattern and relationship that exists between serum lipids and endometrial cancer in a Nigerian setting. Methods: This was a cross-sectional comparative study between patients with endometrial cancer and patients with benign gynaecological conditions, from both the gynaecological out-patient clinics and in-patient wards of the Lagos University Teaching Hospital (LUTH), Lagos. Seventytwo women were recruited for the study comprising of thirty-six women with endometrial cancer and thirty-six women with benign gynaecological conditions. Blood samples were collected from the subjects for serum lipid estimation after interviewer administered questionnaires had been filled following a written informed consent. Data collected were subjected to statistical analysis using the Statistical Package for Social Sciences (SPSS) version 20.