STATEMENT OF THE PROBLEM AND OBJECTIVES OF THE STUDY The undesirable maternal and neonatal side effects of opioid analgesics, and less ready availability and affordability of epidural analgesia in resource poor settings such as Nigeria has necessitated the search for a safe, efficacious, cheap and readily available labour analgesia. Hence, this study was done to determine the efficacy, safety and acceptability of intravenous acetaminophen as an intra-partum analgesic. RESEARCH METHODS. This was a randomized controlled double-blind study involving consenting one hundred and sixty-two pregnant women that met the inclusion criteria. They were recruited in the labour ward, assigned to the study or control group, and each group was administered 900mg of intravenous acetaminophen diluted to 20mls and intravenous normal saline of same volume respectively. The Numeric Rating Scale, hazard ratio and Likert scale were used to measure the degree of pain experienced by women in each group, to compare the time of first demand for rescue analgesia and to measure the level of acceptability respectively. A pre-designed proforma was used in recording outcome measures. Data analysis was done using Statistical Package for Social Sciences version 20. The student’s t-test, chi-square test, Mann-Whitney U test and Fisher’s exact test were used as appropriate for comparison of means and proportions and level of statistical significance was set at p < 0.05.