OBJECTIVE: To determine the effectiveness of Sulphadoxine – pyrimethamine (SP) in intermittent preventive treatment of malaria in pregnancy at Federal Medical centre, Abeokuta. STUDY DESIGN: Randomized control trial SETTING: Antenatal Clinic, Department of Obstetrics and gynaecology, Federal Medical Centre, Abeokuta. POPULATION: Pregnant women presenting for antenatal booking that met the inclusion criteria for the study METHOD: Patients who met the inclusion criteria and who consented to the study were randomized into two groups. Blood film for malaria parasite was collected from all the patients before administering sulphadoxine – pyrimethamine to the first group. A repeat sample for malaria parasite was collected from all the patients after two weeks before administering sulphadoxine – pyrimethamine to the second group. The maternal biodata, Pre and Post SP blood film analysis results were compared within the two groups. MAIN OUTCOME MEASURE: Prevalence of malaria parasitaemia and parasite reduction or clearance rate with use of SP