OBJECTIVES The objective of this study was to assess the influence or effect of vaginal pH on the effectiveness of misoprostol as a means of cervical ripening. Specific objectives were: 1. To determine whether vaginal pH will affect the dose of misoprostol that will achieve cervical ripening. 2. To assess the effect of vaginal pH on the interval between application to cervical ripening. 3. To assess the effect of vaginal pH on the interval between application to onset of uterine contractions. 4. To assess the effect of vaginal pH on the interval between application and delivery of the baby Other outcome measures such as the dose of misoprostol and feto-maternal adverse effects in relation to vaginal pH were assessed. Methodology It was a cross-sectional descriptive study of women scheduled for induction of labour at UCH between December 2010 and January 2011. A total population survey of the women planned for induction was done. Eighty women who consented to the study had their vaginal pH determined before insertion of first dose of misoprostol and based on the result they were categorised into first group of women with vaginal pH< 5 and the second group of women with vaginal pH≥5. The women had their labour supervised by the obstetric team in the Labour ward. A data collecting sheet was used by the investigator to collect data relating to demographic characteristics, labour effects, outcomes of the induction. Data collected was entered into Microsoft Excel (2007) spread sheet and analysed using the SPSS version 17. Quantitative variables were summarized as means and standard deviation while qualitative variables were represented as proportions. The Chi square test and Fisher’s exact test were used to test for associations between categorical variables. Continuous variables were compared using independent t test. Linear regression analysis was conducted to derive significant predictors of misoprostol effect and adjust for the influence of confounding variables.