Objective: To evaluate the effect of prophylactic oral misoprostol on postpartum haemoglobin concentration values compared to control. Methodology: The study was a prospective case controlled study. It was carried out at UNTH and Julius Memorial Hospital, a specialist hospital for women, both in Enugu, Enugu State, Nigeria, between 1st September and 30th November 2012. The study population was booked women who did not have any medical condition or obstetric complications. Main outcome measure was haemoglobin change from the pre-partum value. Secondary outcome measures were misoprostol side effects and need for blood transfusion.