BACKGROUND: Pain continues to be a major challenge for post-operative patients, especially following caesarean section which is a common obstetric procedure. Currently non-steroidal and opiod analgesics are currently the drugs used to combat this condition. As a result of the numerous side effects of these medications, efforts are being put towards identifying new agents that can be used to manage post-operative pain thereby improving patients care post-operatively. OBJECTIVES: To compare the analgesic efficacy of intravenous magnesium sulphate and intramuscular diclofenac in the reduction of pain following caesarean section. METHODOLOGY: Sixty-five eligible patients were randomized into intravenous magnesium sulphate received 50mg/kg body weight of MgSO4 in 250mls of Normal Saline infused over 30minutes as a single dose pre-operatively. Another sixty-five eligible patients were randomized into intramuscular diclofenac sodium administered at the dose of 75mg 12hourly for 24hours. Intramuscular pentazocine at the dose of 1mg/kg body weight was used as rescue analgesia for those the required it based on their pain score within 24hours postoperatively. A visual analogue scale was used to determine the level of pain experienced by the patients and to compare the analgesic efficacy of either arm of drug administered. A structured proforma was used to obtain relevant data from the patients. The generated data was analysed with Statistical Package for Social Sciences (SPSS) version 22. Statistical analysis used Student t test, Chi-square test or Fisher’s exact test, as applicable. A p-value of ≤0.05 was considered significant.