BACKGROUND: Pre-eclampsia is of major health concern globally. Preeclampsia has a significant impact on the mortality and morbidity of pregnant women and their neonates. AIM: The aim was to determine the relationship between maternal serum inhibin A and preeclampsia. OBJECTIVE: The objectives were to determine the level of inhibin A in women with mild and severe preeclampsia, to compare the levels of inhibin A in preeclamptic and normotensive pregnant women and also to determine whether the levels of inhibin A can be correlated with the severity of preeclampsia. METHOD: This was a comparative study. The cases were pregnant women from 26 weeks gestational age diagnosed to have preeclampsia at the antenatal clinic and within the labour ward complex of the Lagos University Teaching Hospital (LUTH) while controls were pregnant women without preeclampsia matched for age, parity and gestational age Preeclampsia was defined as blood pressure of 140/90 mmHg in pregnant women of >20weeks gestation at least during 2 occasions, 6 hours apart with proteinuria of ≥300mg proteinuria in 24 hours urine collection or ≥ 2+ proteinuria on dipstick test with or without oedema.