Resource Page

DETECTION AND CONFIRMATION OF PREMALIGNANT LESIONS OF THE ORAL CAVITY USING TOLUIDINE BLUE AND HISTOPATHOLOGICAL TECHNIQUES AT THE UNIVERSITY COLLEGE HOSPITAL IBADAN, AND THE ADEOYO STATE HOSPITAL IBADAN.

Email:
Supervisor: DR J.O. Lawoyin, DR O.F. Ajayi, DR B. Kolude
Faculty: DENTAL SURGERY
Month: 11
Year: 2004

Abstract

This prospective clinicopathological study is aimed at assessing the usefulness of toluidine blue as a screening tool for oral premalignant lesions. The study included a cohort of 50 patients (25 males and 25 females) with clinically diagnosed premalignant lesions that met preset inclusion criteria. The overall sensitivity and specificity of toluidine blue was 59.1% and 50.0% respectively. The positive and negative predictive values of toluidine blue as screening tests for oral premalignant lesions were 48.2% and 60.9% respectively. Toluidine blue showed high sensitivity in premalignant lesions with severe dysplasia (86.0%) compared with those with moderate and mild dysplasia (71.0% and 25%). The overall positive likelihood ratio for all premalignant lesions was 1.18 whilst negative likelihood ratio was 0.82. In view of the low positive likelihood ratio (<10) and positive predictive value coupled with high negative likelihood ratio (>0.1), caution should be exercised in the use of toluidine blue as screening test, and it should be seen only as an adjunct to clinical examination and histology. There is need for a more elaborate community based study of the toluidine test since small sample size, as in this study, has been documented to result in inaccurate sensitivity and specificity finding.

© 2024 NPMCN, All Rights Reserved
Powered by: