Partly as a result of the high prevalence of gynaecological infective diseases, infertility especially the secondary type seems common in sub-Saharan Africa. The cultural value of child-bearing contributes significantly to the psychosocial consequences faced by couples with infertility on the continent. Assisted reproductive technology (ART) has become popular in infertility treatment but there is limited access to it due to high cost. Scientific literature on the psychological well-being of women undergoing ART in Nigeria is scarce. This study aimed to determine the prevalence and pattern of depressive and anxiety disorders and to evaluate the quality of life among women undergoing ART at a private fertility clinic in Lagos. The study was a cross-sectional and descriptive type. A total of 170 consecutive and consenting women attending the clinic for a fresh ART cycle participated in the study. Socio-demographic and clinical information of the participants were collected using a questionnaire specially designed for the target population. Quality of life was assessed using fertility quality of life questionnaire (FertiQol) and validated by evaluating its concurrent validity with World Health Organization quality of life questionnaire, brief version (WHOQOL-BREF). Participants were interviewed and diagnosis of depressive and anxiety disorders made using relevant modules of Mini International Neuropsychiatric Interview (MINI). Data analysis was done with SPSS, 16th edition to generate relevant statistics. Results were presented with 95% confidence interval and p-values ≤ 0.05 was accepted as being statistically significant. The mean age of the participants was 35.89±6.06. Majority of the participants (57.6%) were 35 years and above, had tertiary education (93.5%), were employed (91.8%) and within the upper income class (81.5%) for developing countries. About 60% had infertility duration ≥ 5 years. About two thirds had secondary infertility and 13% had at least a child. About 45% of the participants had previous IVF cycle. The number of previous IVF cycle ranges from 1 to 12. Of the 4.70% participants who were diagnosed to have depressive disorder, 62.5% admitted having had suicidal thoughts. An anxiety disorder was present in about 23% of the participants. Agoraphobia without panic disorder was the most prevalent anxiety disorder subtype. There was no statistically significant association between psychiatric disorders and any socio-demographic and clinical variables. The mean score for total fertility quality of life was 72.65±13.29. The highest mean score (76.79±13.81) was reported on environmental quality of life domain and the lowest scores on emotional (62.84±18.74) and tolerability (66.43±21.13) domains. Factors associated with poorer quality of life mean scores include age ≥ 35 years (t = 2.153, df = 168, p = 0.033), increasing duration of infertility (F (2,167) = 5.218, p = 0.006), primary infertility (t = 2.966, df = 168, p = 0.003), increasing number of previous IVF cycle (F (2,74) = 4.987, p = 0.009) and not having at least a child (t = 2.402, df = 168, p = 0.017). Prevalence of emotional disorders especially anxiety disorders is high in women undergoing ART compared with the general population. These women would therefore require adequate psychological interventions to cope with infertility and its treatment. The relatively small sample size, non-probability sampling technique and use of a private fertility clinic would limit the generalization of these findings.