INTRODUCTION This study evaluated 5 predictive formulae for calculating creatinine clearance with a view to determining which formula compares best with measured creatinine clearance, obtained with a 24 hour urine collection in SCD patients and controls. METHODS Over a period of 7 months, 100 SCD patients (79 HbSS and 21 HBSC) and 50 controls participated in the study. A case record form was used to capture the clinical details of patients, including the weight, age, and gender, frequency of crises, transfusion and drug history. Sample collected included 7.0ml of venous blood for serum creatinine, full blood count and reticulocyte count estimation. A 24-hr urine and fresh urine samples were also collected for measurement of creatinine clearance and dip stick proteinuria, respectively. Data collected were analysed using descriptive and inferential statistics; a p-value < 0.05 was significant.