BACKGROUND: Preeclampsia is a clinical condition of pregnancy that is characterized with new onset hypertension and proteinuria (300mg or more in 24 hours urine) after 20 weeks of gestation in pregnant women that were previously normotensive with associated high maternal and perinatal morbidity and mortality. The association of malondialdehyde and antioxidant status with severity of preeclampsia is beginning to emerge as a vital predictive tool of severity of preeclampsia. AIMS AND OBJECTIVE: To determine the mean serum level of malondialdehyde, superoxide dismutase, vitamins C and E status in preeclamptic women as well as in the control and to determine the correlation of the results with the severity of preeclampsia. METHODOLOGY: This was a case control study among women with preeclampsia and normotensive women matched for ages, parities and gestational ages as control among women attending antenatal care in UDUTH, Sokoto. Consent was obtained and a proforma used to obtain the necessary information. Blood samples were collected for the analyses of the markers.