Enuresis has been identified as a major renal abnormality in sickle cell patients. Patients with sickle cell disease experience enuresis with greater frequency than the general population. Other renal abnormalities associated with sickle cell anaemia include hyposthenuria, proteinuria, haematuria, glomerular dysfunction and chronic renal failure. Studying the relationship between these other abnormalities with enuresis could be invaluable to clinical evaluation and management of sickle cell nephropathy in children. This descriptive cross-sectional comparative study was thus conducted between July and November 2018 on children aged 5-18 years with sickle cell disease attending the sickle cell disease (SCD) clinic of UITH, Ilorin. The objectives were to determine the prevalence of enuresis among children with sickle cell anaemia in UITH and find out any relationship with hyposthenuria, microalbuminuria and glomerular filtration rate (GFR). A total of 170 children with haemoglobin genotype SS or SC in steady clinical state were recruited from the SCD clinic while an equal number of age and sex-matched apparently healthy children with haemoglobin genotype AA were recruited from the community. The age range was 5-18 years with a mean age of 9.3 ± 3.3 and 9.3 ± 3.5 years for subjects and controls respectively. The prevalence of enuresis among the subjects was 39.4% which is significantly higher than the 21.8% in the controls (p=0.0001). The prevalence reduced with increasing age for both the subjects and controls. Enuresis was more prevalent in males than females in both the subjects and the controls.