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CORRELATION OF CLINICAL, ENDOSCOPIC AND PATHOLOGICAL FINDINGS AMONG SUSPECTED PEPTIC ULCER DISEASE PATIENTS IN NATIONAL HOSPITAL ABUJA

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Supervisor: Prof. A.M.E Nwofor, Dr. O.O. Olaomi, Dr. P.G. Jibrin
Faculty: SURGERY
Institution of Training: National Hospital Abuja, Nigeria
Month: 11
Year: 2014

Abstract

Background: Peptic ulcer disease remains one of the most prevalent gastrointestinal diseases and has been linked to H. Pylori infection. This condition may be suspected on clinical grounds, but diagnosis is established using upper gastrointestinal endoscopy. Aims: To determine the correlation between the endoscopic and pathological findings among suspected peptic ulcer disease patients who have been referred for diagnostic upper gastrointestinal endoscopy in National Hospital Abuja. Methods: This is a hospital based prospective study conducted among suspected PUD patients at National Hospital, Abuja from May 2013 to June 2014. Clinical endoscopic and histological findings were ascertained and documented. Data obtained were analyzed using SPSS version 21.0. Tests of significance were done using Chi square test and student t test at 95% confidence intervals. Results: One hundred and thirty two patients were included in the study. The ages ranged from 15 to 87 years; mean age 43.30±11.94 years. Seventy-seven (58.3%) patients had abnormal endoscopic findings, of which 37 (28.0%) had PUD. Prevalence of H. Pylori infection was 42.2% and was found in 81.1% of PUD patients. H. Pylori was significantly associated with confirmed PUD (p<0.001) and abnormal endoscopic findings (p<0.001). No association was found between normal endoscopic findings and histological findings (p= 0.924). Conclusion: There is a poor correlation between clinical and endoscopic diagnosis of PUD. H.Pylori was found to be significantly associated with PUD and abnormal endoscopic findings. Endoscopic facilities should therefore be made available and accessible for proper PUD diagnosis. Empirical treatment of H. Pylori in patients with diagnosed PUD is strongly recommended.

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