Background: Benign Prostatic Hypertrophy (BPH) is a common urological condition in men above 50 years. It is an important cause of sub-vesical obstruction. Urodynamic studies remain the gold standard for diagnosis of BOO. Ultrasound measurement of prostate volume is non invasive, easily available and a cost effective method useful in assessing BOO. IPSS on the other hand, objectively assesses symptoms severity in BOO patients. If prostate volume correlates with IPSS, possible outcomes of further investigations and treatment can be predicted thereby reducing delay to appropriate choice of treatment . Objective: This study was aimed at determining the correlation between ultrasound measured prostate volume and IPSS in men with Benign Prostatic Hypertrophy. Methodology: This was a hospital based cross-sectional prospective study of new symptomatic BPH patients. Following ethical approval from the Nnamdi Azikiwe University ethical committee, 100 patients who met the inclusion criteria and were diagnosed with clinical BPH were enrolled. They had no other identifiable cause of bladder outlet obstruction except BPH after clinical evaluation. The International Prostate Symptoms Score (IPSS), Quality of life score (QOL),and Prostate volumes were measured. Aloka Prosound SSD3500 (Aloka Co Ltd, Tokyo, Japan) probe frequency 3.5 MHz was used in trans-abdominal ultrasound of the prostate. Correlation between prostate volume, IPSS and QOL were done using SPSS version 20 (IBM, SPSS,Chicago, IL, USA) . P value <0.05 was considered significant. Results: The mean age of patients was 69.3 ± 10.6 years with a range of 48 to 100 years. The mean prostate volume, IPSS and QOL were 96.0cm3 ± 70.5cm3, 15.63 ± 8.6 and 4.8 ± 1.3 respectively. Nineteen patients had prominent median lobes. The highest recorded IPSS was 35 and the lowest was 4, while the smallest and largest recorded prostate volumes were 19cm3 and 350cm3 respectively. Nocturia was the major IPSS sub score. There was a weak positive correlation between prostate volume and IPSS in men with BPH (r=+0.109; p = 0.28) and between prostate volume and quality of life (r=+0.072; p=0.45). There was also a weak positive correlation between patients with only severe scores and corresponding prostate volumes (r= +0.122, p=0.125). The correlation between patients with severe scores and their corresponding QOL was strong (r=+0.537, p=0.135 respectively). These findings were however, not statistically significant. Conclusion: There is a weak positive correlation between prostate volume measured by ultrasound and symptoms severity scores in patients with BPH, though not statistically significant. This may be as a result of the small sample size. A larger sample size may be able to achieve statistical significance. Keywords: Benign prostatic Hypertrophy, Prostate volume, detrusor wall thickness, median lobe, quality of life, International prostate symptoms score.