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CORRELATION BETWEEN FLOW RATE VARIABLES OF UROFLOWMETRY AND PROSTATE VOLUME IN BENIGN PROSTATIC HYPERPLASIA PATIENTS AT UNTH, ITUKU-OZALLA

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Supervisor: DR MBADWE I M, DR AMU O C
Faculty: SURGERY
Month: 11
Year: 2022

Abstract

SUMMARY Prostate gland is a male accessory sex gland. The organ tends to grow and enlarge as a man gets older. It is divided into zones. The most common zone which undergoes hyperplasia is the transition zone. Benign prostatic hyperplasia is the most common neoplasm in elderly men. BPH is a significant health care problem in Nigeria due to its high prevalence and associated high treatment cost. It significantly affects the quality of life of affected men. As the prostate enlarges, it usually obstructs the outflow of urine from the urinary bladder. It is the most common cause of bladder outlet obstruction in elderly men. However, studies have shown that the size of the prostate does not correlate with the severity of symptoms. The volume of prostate can be determined by ultrasound. Transrectal ultrasound of the prostate is preferably used to determine the size of the gland. Uroflowmetry is the timed measurement of urinary flow using the uroflowmeter. The major parameters obtained from the uroflowmeter include flow rate variables for example peak flow rate and average flow rate. The values of uroflowmetry are affected by various pathologies associated with bladder outlet obstruction. It is pertinent to note that there are other causes of bladder outlet obstruction besides benign prostatic hyperplasia. The common ones include prostate cancer and urethral stricture but these formed part of the exclusion criteria in this study. This study highlighted the relationship between the volume of the gland obtained through transrectal ultrasound and the values of flow rate variables obtained from uroflowmetry. Furthermore, the study also looked at the relationship between peak flow rate and international prostate symptom score. The flow rate variables which I used in this study are peak flowrate and average flow rate. OBJECTIVE 1. To determine therelationship between uroflowmetry parameters and prostate volume. 2. To determine the relationship between international prostate symptom score and peak flow rate. METHODOLOGY Consenting men within the inclusion criteria (lower urinary tract symptoms from clinical BPH, more than 40 years old,no history of previous medication ), presenting at the urology outpatient clinic in UNTH were selected for the study with the objective of determining any significant relationship between flow rate variables of uroflowmetry and prostate volume. After history taking, I administered the IPSS and physical examination was done, eligible men were sent for urodynamic study. I performed the uroflowmetry and recorded the values obtained. They were subsequently sent for transrectal ultrasound in the radiology department of the same hospital and ultrasound determination of prostate volume which was performed by the same radiologist and myself. The data collected were analyzed using both descriptive and inferential statistics. The descriptive statistics was used to determine– frequency, percentage, mean, standard deviation, median and the inferential statistics-was used to determine Spearmans correlation with the aid of statistical package for social sciences SPSS version 25 and Microsoft excel 2007. xiv RESULTS A total of 79 patients were enrolled for the study.The range of ages of the patients was 40 – 96 years with a mean and standard deviation of 64.7 years ±10.7.The international prostate symptom score had a range of 6 to 34with mean and standard deviation of 14.52±6.22.The range of values of prostate volume was 25 to 295mlwith amean prostate volume of 59.5ml±41.26and meanof peak flow velocity of the patients was15.16ml/s ± 9.43 with a range of 2 to 69ml/s.The range of the average flow rate was 1 to 32 ml/s with a mean value of 6.43ml/s ±4.36. The range of the PSA values was 2-7 ng / ml with a mean and standard deviation of4.05ng/ml±6.22. It was observed that prostate volume and flow rate variables of uroflowmetry were not statistically related although they both had a negatively trended relationship.Furthermore, it was also seen that international prostate symptom score had an inverse relationship with peak flow rate.

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