Background: The global burden of surgical site infection (SSI) is enormous. Surgical site infection has always been a common complication of surgery and trauma at all times and climes. The rate of SSI varies with degree of contamination of the wound. Among many factors thought to influence the infection rate of any wound type is skin wound closure technique. Aim and Objectives: To determine the effects of the two commonly used skin wound closure techniques (continuous subcuticular and simple interrupted techniques) on SSI rate of contaminated general surgical laparotomy wounds in UCTH, Calabar and common causative microbial organisms responsible for SSI of contaminated general surgical laparotomy wounds in the study. Methodology: Study is a randomized controlled study carried out in the University of Calabar Teaching Hospital over a twelve month period using a designed research protocol and proforma. A total of one hundred and four patients whose wounds were classified as contaminated, were randomised into simple interrupted skin closure group(A), and continuous subcuticular skin closure group(B) by assigning them to one of the two skin wound closure techniques using block (restricted) randomization method. The wounds were closed primarily using these two methods under antibiotic cover. The rate of SSI in both arms of the study was determined and compared. Those that developed SSI were evaluated, causative microbial organisms isolated and appropriate treatment instituted. Data analysis: Data was analyzed using statistical package for social sciences (SPSS) version 21.0. Comparison of SSI rate between the two groups was made using chi-square analyses. Chi-xiv square was also used to analyse other categorical variables while independent T-test was used to analyse quantitative variables. Results: A total of 104 surgical patients randomized into continuous subcuticular (52) and simple interrupted (52) groups were recruited into the study. The mean ages were 36.21 ± 18.29 and 37.69 ± 17.47 consecutively. Male – female ratio were 1:1 and 1.5:1 for the continuous subcuticular and simple interrupted group respectively. The overall SSI rate of contaminated general surgical laparotomy wounds in the study population was 14.4%. This study showed a slightly lower SSI rate among the CS group (13.5%) compared to SI group (15.4%). This difference is, however, not statistically significant (p-value 0.780). We also found that E. coli (44.4%) and S. aureus (33.3%) are the commonest organisms responsible for SSI in this study. It was also observed that these causative bacteria, though sensitive to some common antibiotics are largely multidrug resistance.