BACKGROUND:Intrauterinefetaldeathisanundesirableoutcomeofpregnancyandis emotionallydistressingforboththeparents,theirextendedfamilyandmanaginghealth personnel.Quickdiscontinuationofpregnancyfollowingintra-uterinefetaldemiseis oftendesired,however,spontaneouslabouranddeliverymaynotoccurformanydays andretentionofadeadfetusin-uterohaspotentiallifethreateningmedicaland psychologicalsequelae.Therefore,aneffective,safeandtimelymethodofinductionof labourisnecessarytoreducethesetime-relatedadverseeffects. AIM:Theobjectiveofthestudywastocomparetheefficacyandsafetyofcombination ofmifepristoneandmisoprostolwithmisoprostolaloneforinductionoflabourin pregnanciescomplicatedbyintrauterinefetaldeath. METHOD:Itwasatripleblindedrandomizedcontrolledtrialinvolving80consenting womenwithintrauterinefetaldeathatDeltaStateUniversityTeachingHospital,Oghara, CentralHospital,WarriandEkpanGeneralHospital,Warri,allinDeltaState.Participants wererandomized intotwogroupsof40participantseach.Thetreatmentgroup receivedasingleoraldoseof200mgmifepristone,followedbyinductionoflabourwith 6-hourly50µgmisoprostolinsertionintotheposteriorfornixofthevaginaafter24hours interval.Thecontrolgroup receivedaplacebocontaininglactose(similarto200mg mifepristone),followedbyinductionoflabourwith6-hourly50µgmisoprostolinsertion intotheposteriorfornixofthevaginaafter24hoursinterval.Ineachgroup,6dosesof misoprostol constituteacourseofmisoprostol.Iffirstcoursewasunsuccessful, secondcourseofmisoprostolwasstartedaftera12hourbreak.Theprimaryoutcome measurewasinductiontodeliveryinterval,whilethesecondaryoutcomeswerethe x numbersandtotaldoseofmisoprostolused,needforaugmentationoflabourwith oxytocin,psychologicalstress,retainedplacenta,primarypostpartum haemorrhage, uterine rupture,side effects ofmisoprostollike nausea,vomiting and diarrhea, participantsperceptionofpain/discomfortandsatisfaction.