Background: Despite years of research the aetiopathogenesis of preeclampsia has remained elusive. Recent evidence has implicated oxidative stress in its pathogenesis. Selenium has been found to be reduced in pregnancies complicated with the disorder. Its anti-oxidative role in the development of preeclampsia is a subject of current research. Therefore determining the selenium status of women diagnosed with preeclampsia will elucidate its possible association with this condition in our environment. Aim: To compare the mean serum selenium level of pregnant women diagnosed with preeclampsia with that in normotensive pregnant women. Materials and Methods: This study was a case control study carried out in FMC, Umuahia. Group 1 was made up of preeclamptics after 28 weeks gestational age, while group 2 consisted of normal pregnant women after the 28 weeks gestational. Data analysis was done using SPSS version 20. Tests of statistical significance were carried out using student t-test, Chi-squared test, and Spearman rank order correlation. A P-value of less than 0.05 was considered significant at 95% confidence interval.