To compare the intraocular pressure measured with Goldmann applanation tonometer and Icare rebound tonometer in patients attending the glaucoma outpatient clinic of Federal Medical Centre, Asaba, Delta State with a view to making appropriate recommendations to relevant authorities. Method This was a hospital based, cross sectional comparative study that was carried out over a period of six months, in the eye clinic of Federal Medical Centre, Asaba, Delta State. Systematic random sampling technique was used to select eligible participants for the study. Interviewer administered questionnaire was used to obtain demographic data, history and acceptability of the two tonometers. General and ophthalmic examinations were carried out. Tonometry using Icare and Goldmann tonometers, and pachymetry using ultrasound pachymeter were performed in that order. The data collected was entered and analyzed on International Business Machine Statistical Package for scientific solutions (IBM SPSS) software, version 21.0. These were presented using frequencies, proportions and mean. Bland-Altman plots were used to determine the agreement between the Intraocular pressure (IOP) values obtained with the two tonometers. Pearson’s linear regression analysis was used to determine the effect of central corneal thickness on the Intraocular pressures obtained with the tonometers. Statistical significance level was set at p < 0.05. xiv Results Data from two hundred and sixty participants were analysed. The mean intraocular pressures were 18.189 ± 6.794mmHg and 18.385 ± 5.908mmHg for Icare tonometer and Goldmann applanation tonometer respectively. There was significant high correlation (r = 0.957, p < 0.001) between the mean intraocular pressure values obtained with the two tonometers. Bland Altmans plot showed good agreement between the intraocular pressures measured with the tonometers. There was no statistically significant difference in the mean intraocular pressure value (ΔIOP = -0.196 ± 2.062, p = 0.126). The difference in intraocular pressure values between the two tonometers was within ± 2mmHg and ± 3mmHg in 80.0% and 85.8% of measurements respectively, while 6.9% had difference in intraocular pressure greater or equal to ± 5mmhg. Subgroup analysis of intraocular pressure showed that Icare tonometer underestimated intraocular pressure obtained with Goldmann tonometer in the 7 – 22mmHg pressure ranges while it overestimated this in the 23mmHg – 50mmHg range. The mean central corneal thickness was 529.60 ± 34.90 μm, there was significant very weak positive correlation between the central corneal thickness and intraocular pressure obtained with Icare tonometer (r = 0.124, p = 0.046) while the correlation between central corneal thickness and intraocular pressure obtained with Goldmann tonometer was not statistically significant (r = 0.120, p = 0.053). There was statistically significant very high correlation (r = 1.000, p < 0.001) between the mean corrected intraocular pressure obtained with the tonometers. Almost all participants (99.6%) found Icare tonometer more acceptable than goldmann tonometer.