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COMPARISON OF IMMEDIATE AND DELAYED INDUCTION OF LABOUR FOR TERM PRE-LABOUR RUPTURE OF MEMBRANE IN DELTA STATE, NIGERIA: A RANDOMIZED CONTROLLED TRIAL

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Supervisor: PROF. PATRICK OKONTA
Faculty: OBSTETRICS AND GYNAECOLOGY
Month: 11
Year: 2021

Abstract

BACKGROUND The two options of management for Pre-labour rupture of membrane (PROM) at term are immediate induction of labour and delayed induction of labour. The better of these in our environment, remains unresolved by currently available evidence. AIM AND OBJECTIVES The aim of the study was to compare the fetal and maternal outcome in women who had immediate induction of labour and those who had delayed induction of labour following term-PROM. The objectives was to compare incidence of clinical chorioamnionitis, diagnosis of labour to delivery interval, caesarean delivery rate, low fifth minute Apgar scores, puerperal sepsis, and neonatal sepsis among women who had immediate induction of labour and those who had delayed induction of labour following term-PROM RESEARCH METHOD This study was a three-centre randomized controlled trial. Three hundred and thirty four consenting participants who presented with PROM at term with no uterine contraction were randomly allocated either to the intervention arm (immediate induction n=167) or control arm (delayed induction n=167). The primary outcome measure was incidence of clinical chorioamnionitis while the secondary outcome measures were diagnosis-to-delivery interval, requirement for caesarean delivery, incidence of low fifth-minute Apgar scores, incidence of puerperal sepsis, and incidence of neonatal sepsis. Data was collected on baseline demographic, xii obstetrics characteristics, and the outcome measures. Data was analyzed using statistical package for social sciences version 22(IBM ® Inc, USA). Analysis was by intention to treat. Comparison of patients’ characteristics and outcome measures between the two groups was conducted using the Chi Square tests for categorical variables, and the Student’s t-test for continuous variables. Level of statistical significance was set at 5%, confidence interval at 95%.

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