INTRODUCTION: Vaginal misoprostol has been found to be a very effective method of cervical ripening and induction of labour; however, it is associated with some complications. Therefore, there is need to search for other routes of administration that are safer, acceptable, and as effective as the vaginal route. OBJECTIVE: To compare the effectiveness and safety of vaginal and sublingual misoprostol for cervical ripening and induction of labour. METHOD: This was a comparative study carried out among booked antenatal cases. The experimental group consisted of eligible women scheduled for cervical ripening and induction of labour. Participants were interviewed using a structured questionnaire after obtaining informed consent. On admission into the labour ward, each eligible woman was recruited consecutively and randomized into one of the groups. Outcome measures including delivery within 24 hours, induction to delivery interval, caesarean section rate, side effects of misoprostol, Apgar Score at birth and admission into Neonatal Intensive Care Unit for both routes of misoprostol administration were determined.