The cytopathological diagnosis of 151 reports on peripheral lymph node lesion samples obtained by find needle aspiration (FNA) done at the Morbid Anatomy Department of the Lagos University Teaching Hospital, Lagos over a period of three years and six month (Jan 2001 – June 2004) were analysed. The cytopathological diagnosis of 65 sample with corresponding histopathological diagnosis were also compared. Inflammatory lesions constitute the majority of the reports: 82 out of 151 reports (52%), while primary lymphoid Neoplasms and metastatic lesions constitute 39% and 18% respectively. Only 12 (7%) of the reports showed inadequate sample for cytopathological diagnosis. In this study, the overall sensitivity and specificity of FNA for cytology in the diagnosis of peripheral lymphoid lesions are 77.8% and 15.2% respectively. Also, the positive predictive value of this procedure is 82.5%. For non specific lymphadenopathy, the sensitivity and specificity of 78.6% and 93.3% were obtained respectively. The positive predictive value of this procedure in the diagnosis of non specific inflaminatory lesions of peripheral lymph node is 78.6%. For chronic granulomatous lesions of lymph node, sensitivity and specificity of 83.3% and 97.0% respectively were obtained. The positive predictive value is 91.0%. For primary lymphoid neoplasms (lymphomas). This procedure has sensitivity and specificity of 80.0% and 95% respectively. Positive predictive value of 88.9% was obtained in the study. FNA for cytology, in this study, has a sensitivity and specificity of 92.4% and 100% respectively. The positive predictive value of the procedure in the diagnosis of metastatic lymph node lesions is 100%. In this study, the sensitivity and specificity of FNA for cytology in the diagnosis of lymph node lesions are similar to those reported in the literatures. Also, the limitations of the procedure are also similar to other similar studies. It could be concluded in this study, that FNA for cytology, is a valuable technique to detect potentially lethal diseases such as Tuberculosis and cancers and could be used for their early detection. The availability of other ancillary techniques will only add to its accuracy and be of use in the subs classification of primary lymphoid neoplasms and also to be a guide in controversial diagnosis.