Background: Sickle cell anaemia is the commonest haemoglobinopathy in pregnant Nigerian women, and cardiac manifestations are a significant feature of the disease especially in pregnancy. Pregnant women with sickle cell anaemia are at high risk of morbidity and mortality and cardiac dysfunction in them increases this risk and may compromise their post-partum health. Knowledge of optimal cardiac function during pregnancy as well as the post-partum period would help identify and promptly manage cardiac dysfunction in them when it occurs. Objective: The aim of this study was to assess and compare the cardiac function between pregnant women with HBSS and those with HBAA using echocardiography in LUTH. Study Design: A longitudinal comparative study. Study Area: Antenatal clinic, labour ward, and cardiovascular laboratory of LUTH. Methodology: A total of 40 women were recruited for the study, of which 20 pregnant HBSS were cases and 20 pregnant HBAA women were controls. Echocardiographic studies were performed in the third trimester of pregnancy. They were followed up till delivery, and a follow up Echocardiography was performed after 6 weeks post-partum. Paired t-test, student’s t-test and Pearson’s chi-square were used to respectively compare cardiovascular structure and function during the antepartum and post-partum state and between HBSS and HBAA participants.