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COMPARATIVE STUDY ON THE INCIDENCE AND RISK FACTORS OF CERVICAL DYSPLASIA AMONG HIV POSITIVE AND HIV NEGATIVE WOMEN AT AMINU KANO TEACHING HOSPITAL

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Supervisor: Prof Yakasai, Prof Omole Ohonsi
Faculty: OBSTETRICS AND GYNAECOLOGY
Institution of Training: AMINU KANO TEACHING HOSPITAL
Month: 11
Year: 2016

Abstract

Background HIV infection is a risk factor for cervical cancer and both diseases are prevalent in Nigeria. HIV positive women are at greater risk of cervical dysplasia than HIV negative women which may be as a result of immunosupression, hence adding more burden to their already worsening health. It has become relevant to screen these women early and refer for appropriate and effective therapeutic intervention. Aims/Objective To compare the incidence and risk factors of cervical dysplasia among HIV positive and HIV negative women at Aminu Kano Teaching Hospital, Kano. Research Methods This was a comparative cross sectional study conducted at Aminu Kano Teaching Hospital, which involved HIV positive women attending HIV clinic and HIV negative women attending the gynecological clinic at Aminu Kano Teaching Hospital. A cohort of consenting 150 HIV positive women not on HAART and 150 HIV negative women , which had been selected by systematic random sampling were sent for Pap smear examination. On the same day blood samples were taken from antecubital vein and sent for both CD4 count and viral load among the HIV positive group. A pretested questionnaire was administered to the women of both groups on same day to determine the presence or absence of risk factors of cervical dysplasia in them. The results obtained were recorded using proforma and analyses of risk factors of cervical dysplasia was done using Chi square test and Fisher exact test to compare variables between those with normal and abnormal smears and student t test to determine the relationship of lesions with CD4count and viral load among the HIV positive women.

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