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COMPARATIVE STUDY ON PREVALENCE AND RISK FACTORS FOR DYSLIPIDAEMIA IN HIV-INFECTED AND UNINFECTED CHILDREN SEEN AT THE AMINU KANO TEACHING HOSPITAL, KANO, NIGERIA.

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Supervisor: Professor H.A. Aikhionbare, Professor O. A. Oyelami, and Dr. F. Hassan- Hanga
Faculty: PAEDIATRICS
Month: 05
Year: 2018

Abstract

HIV infection has become a chronic disease in paediatric patients as a result of access to AntiRetroviral Therapy (ART), which has significantly improved the prognosis and potential for longterm survival. However, prolonged administration of these drugs (ART) is associated with metabolic side effects, especially dyslipidaemia with potential increase in the risk of development of cardiovascular disease as the affected children mature into adults. The aim of the study was to ascertain the prevalence and risk factors for dyslipidaemia among HIV infected children aged 2-15 years seen at the Aminu Kano Teaching Hospital (AKTH), Kano. This comparative cross sectional study was conducted on two hundred and forty subjects from August, 2015 to March, 2016. The subjects were made up of three groups of eighty HIV-infected children on Highly Active Antiretroviral Therapy (HAART), eighty HIV-infected HAART naive children and eighty HIV-negative age- and sex-matched apparently healthy children. Their biodata, socio-demographic characteristics and physical examination findings (anthropometric measurements inclusive) were recorded. Blood samples were also collected from each subject and their lipid concentrations measured using enzymatic methods. The prevalence of hypertriglyceridaemia was 62.5%, 47.5%, and 40% in HIV-infected children on HAART, HIV-infected HAART naïve and HIV-uninfected children respectively. The difference in prevalence was statistically significant (χ2 =43.15, p=0.0001). Hypercholesterolaemia was present in 47.5%, 11.3% and 8.7% in HIV-infected children on HAART, HIV-infected HAART naïve children and HIV-uninfected children respectively. The difference in prevalence was statistically significant (χ2 =8.40, p=0.014).

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