Background: Cigarette smoking and Anxiety Disorders occur commonly in schizophrenia but are often overlooked by psychiatrists in the management of their cases. Their presence may compound the challenges faced by these patients and may contribute to poor outcome. Objectives: The purpose of this study was to determine the prevalence of comorbid smoking and anxiety disorder among the participants with schizophrenia, and the association between comorbidity and socio-demographic variables, dosage of antipsychotics prescribed and disability. Method: A total of 367 participants were recruited. Case note diagnosis of schizophrenia was confirmed using Schedules for Clinical Assessment in Neuropsychiatry (Present State Examination Schizophrenia component). Sociodemographic questionnaire was administered to to all the participants assess their sociodemographic characteristics. The Positive and Negative Syndrome Scale was used to measure the symptoms of schizophrenia while the 12 Item Version of the World Health Organization Disability Assessment Schedule was used to measure disability in all the participants. Present State Examination Anxiety section was used to detect the presence of anxiety disorder and for those who had any anxiety disorder, the Anxiety Status Inventory was used to measure the severity of anxiety. And for those that screened positive to smoking Present State Examination: tobacco section was administered to determine the rate of smoking. Statistical analysis was done with SPSS (version 15). Results: A total of 189 females (51.5%) and 178 (48.5%) males were studied. The mean age of the participants was 34.1± 9.94years. Most (65.7%) have never being married. Most (55.3%) had secondary school education. A lifetime prevalence of 25.9% and 12.3% were reported for cigarette smoking and anxiety disorder respectively. All those that smoked were males. Specific prevalence for anxiety disorder in schizophrenia were generalized anxiety disorder 6.3%, obsessive compulsive disorder 3.3%, and phobic anxiety disorder 2.7%. Current smoking was associated with increased disability (t=2.32, p=0.02) among the participants studied. None of the females smoked. Among those that smoked being unmarried (ϰ²=6.51, p= 0.01) and unemployed (ϰ²=5.11, p=0.02) were associated with prescription of high doses of antipsychotics. Anxiety disorder was associated with increased disability (t=3.50, p=0.001) and psychopathology (t=3.40, p=0.001) among the participants studied. Generalized Anxiety disorder was more likely in females (ϰ²=4.93, p=0.03). Phobias were associated with prescription of low doses of antipsychotics (ϰ²=4.08, p=0.04). There was a low rate of identification of anxiety disorder in routine clinical practice (k=0.08, p=0.00). Conclusion: Comorbid smoking and anxiety disorders are common in schizophrenia and they are associated with increased disability. Also these disorders are poorly detected in our environment