Background & Aims: The most recent study on the clinicopathological features of gastric carcinoma from the University College Hospital (UCH), Ibadan, was done in 2000. The aims of this study were to (i) update the knowledge on the clinicopathological features of gastric carcinoma diagnosed in the Pathology Department of the UCH Ibadan between 2000 and 2011 (ii) define the rate of MSI in gastric carcinoma (iii) compare the clinicopathological features of MSI and MSS tumours. Materials & Methods: The clinical and demographic data and histological diagnoses of patients diagnosed between 2000 and 2011 were retrieved from the UCH Cancer Registry, the Pathology Department records and from the UCH Medical Records. Also, slides were made from archival samples of the same patients and reviewed to confirm the histological diagnoses, subtype the tumour and determine the presence/ absence of other clinicopathological parameters. MSI was assessed on 47 archival samples (formalin-fixed, paraffin-embedded gastric carcinoma tissue samples) using High Resolution Melt Curve Analysis on BAT 25 and BAT 26 microsatellite loci. Statistical analyses were done using SPSS version 19.