Background: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an emerging healthcare associated pathogen. Objective: To determine the prevalence of CRKP at the Lagos University Teaching Hospital (LUTH) and identify associated risk factors. Setting: LUTH is a 761-bed tertiary care teaching hospital. Methods: Inpatients with clinical specimen that grew Klebsiella pneumoniae were identified from the microbiology laboratory and followed up in the ward where clinical data were collected. Antimicrobial susceptibility testing was done on the isolates using the modified Kirby Bauer method. Carbapenemase production was confirmed by the modified Hodge test and screening for ESBL production, by the double disk synergy test. CRKP were compared with non CRKP to identify risk factors.