Introduction: Uterine fibroids are common in women of reproductive age group. Black race is a risk factor for oxidative stress as well uterine fibroids. Reactive oxygen species have been implicated in the development of pro-fibrotic diseases including uterine fibroids. There is paucity of data on the possible link between oxidative stress and uterine fibroids among black women of reproductive age. Aim: The aim of this study was to measure and compare the serum levels of antioxidants and oxidants in women with and without uterine fibroids. Methods: A total of 88 women were recruited. Blood samples were obtained and analysed for serum levels of selected antioxidants and oxidants. Pelvic ultrasound scan was carried out on all participants. Mann-Whitney U Test and Student’s t-test were used for comparison of continuous variables; Chi square test was used for categorical variables. Simple linear and multiple regression analysis were conducted. A p-value < 0.05 was considered statistically significant.