Assessment of body composition provides a more useful and complete data relating to nutritional status. Most studies on the size of children with Sickle cell anaemia (SCA) are limited to composite measures of weight, height, and BMI without reference to body composition. This has left a gap in the knowledge of the relative impact of the disease on body composition in terms of Percentage Body Fat, Fat Mass and Fat Free Mass (PBF, FM and FFM). The aim of the current study was to evaluate body composition of children with sickle cell anaemia aged 5 – 18 years who attend the Haematology clinics of General Hospital Gbagada and Massey Street Children’s Hospital. The present study was descriptive, comparative and cross sectional. It was carried out over a period of six months (February 2016 to July 2016). A total of 480 children aged five to eighteen years were recruited following parental consent and assent from the children seven years and above. Two hundred forty children with SCA in steady state and 240 age and sex matched children with HbAA controls were studied. All subjects and controls had body composition measured by bioelectrical impedance analysis (BIA) and from two skin fold thicknesses (subscapular SFT and triceps SFT). Percentage body fat (PBF), fat free mass (FFM) and fat mass (FM) were estimated from both methods.