Background and Aims: Barrett’s oesophagus (BE), a complication of gastroesophageal reflux disease (GERD) is reported to be rare in black Africans with lack of data from Nigeria concerning its prevalence and risk factors. This study aimed to investigate the prevalence, clinical characteristics and risk factors of BE in Nigerian patients with GERD. Methods: A cross-sectional study was conducted on consecutive consenting adult patients with upper gastrointestinal symptoms presenting to the endoscopy unit of a tertiary health facility in Lagos. Carlsson-Dent (CD) questionnaire was used to diagnose GERD. Socio-demographic characteristics and potential risk factors for BE were documented. All recruited GERD patients underwent upper gastrointestinal endoscopy. Patients with endoscopically suspected oesophageal metaplasia (ESEM) underwent four-quadrant biopsy; BE was histologically defined as Columnar lined epithelium (CLE) with or without specialized intestinal mucosa (SIM). GERD patients without CLE at endoscopy were considered as controls and compared to GERD patients with BE and those with SIM. Logistics regression analysis was used to evaluate for independent risk factors of BE. Results: Of the 132 recruited patients, 49 (37.1%) were diagnosed as having GERD using the CD questionnaire. Eight patients with GERD had CLE on histology (16.3%); 2 (4.1%) of these had SIM. Compared to patients without BE, presence of hiatus hernia (HH) and higher body mass index (BMI) were significant risk factors for BE. On logistics regression only HH [OR 9.300; 95% CI, 1.613-53.618; P=0.013] was found to be an independent risk factor for BE in GERD patients.