Objective: The study aims to determine the bacteriological profile and sensitivity pattern of endocervical isolates in septic abortion patients at the Lagos Island Maternity Hospital, with a view of recommending appropriate 1st-line antibiotic regimen for the management of Septic abortion cases. Design: This was be a prospective cross sectional study. Materials and Methods: A standard questionnaire was administered to a total of 234 consenting patients (with signs and symptoms suggestive of septic abortion), who were recruited for the study between 1st February 2011 and 31st January, 2012. Endocervical swabs obtained before commencement of antibiotics were transported in peptone broth to the laboratory; isolates were identified by standard microbiology techniques and were subjected to antibiotic sensitivity tests.