BACKGROUND: Rubella virus infection is one of the common viral conditions in pregnancy that may result in recurrent fœtal wastage, fœtal death or congenital rubella syndrome. This is a frustrating experience which can be physically and emotionally tasking for couples. OBJECTIVE: To compare the prevalence of rubella virus infection among women with recurrent pregnancy loss and normal post- natal women. DESIGN : It was a hospital based case control study METHODOLOGY : In this study 60 consenting women with recurrent pregnancy loss were recruited as cases, and another 60 consenting women presenting to the postnatal clinic following delivery of a healthy baby with no prior history of recurrent miscarriages, constituted the control group. Blood samples from cases and controls were analyzed for Rubella specific IgG and IgM using Enzyme Linked Iimmunosorbent Assay (ELISA) test kits. A semi-structured researcher administered questionnaire was used to obtain socio-demographic information which included; age, socioeconomic class, parity and gestational age at pregnancy loss. Data was analysed using Statistical Package for Social Sciences version 20. Statistical test employed Chi square and independent t test to determine significant difference between cases and controls. A p-value of less than 0.05 was considered significant.