Background: Hypertensive disorders of pregnancy which include preeclampsia is a major contributor to maternal mortality worldwide. Every year, preeclampsia accounts for 100,000 maternal deaths worldwide and this high incidence makes its prevention and effective management very important. Numerous early predictors and biomarkers for this pregnancy complication have been postulated but none is yet to find universal acceptance. Objective: This study compared levels of maternal serum CA125 in normal pregnancies and pregnancies complicated with preeclampsia to see if there is any relationship or relevance of this marker with preeclampsia, its diagnosis and/or management. Design: A Comparative study comprising of 70 pregnant women with preeclampsia (cases) and 70 normotensive women as controls. Methodology: Using a proforma, information on the socio-demographic data and obstetric profile were obtained from both cases and control. 5 mls of maternal venous blood was collected after obtaining consent from both cases and control. All the women were followed up till delivery and records of the delivery and neonatal outcomes were obtained subsequently. Serum CA125 levels were determined by standard enzyme-linked immunosorbent assay (ELISA). Statistical analysis was done using SPSS version 19 software package.