BACKGROUND Preeclampsia is a hypertensive disorder peculiar to pregnancy with a worldwide prevalence of about 5-8%. It is a systemic syndrome that appears to originate in the placenta and is characterized by widespread maternal endothelial dysfunction. Reliable prediction of preeclampsia and related clinical maternal and fetal adverse outcomes is a high unmet medical need in pregnancy care. AIM AND OBJECTIVES To determine the association between angiogenic factors and preeclampsia and its relationship with severity of the disease if any. MATERIALS AND METHOD This case-control study was carried out on pregnant womenat >20 weeks of gestation presenting at antenatal clinic of Usmanu Danfodiyo University Teaching Hospital from 1st April, 2020 to 31st December, 2020. Women with pre-eclampsia were consecutively recruited as cases while women without preeclampsia matched for gestational age, age and parity were similarly recruited as controls. A detailed history was taken and thorough examination was carried out on the participants. A pretested structured interviewer administered questionnaire was completed by the participants. Blood samples were taken from both cases and controls for measurement of soluble Fms-like tyrosine kinase 1 (sFlt-1) and Placental growth factor (PlGF) and the ratio of sFlt-1 to PlGF calculated. The cases were divided into two groups: Group A- women with early onset preeclampsia of gestational age < 34 weeks and Group B- women with late onset preeclampsia of gestational age > 34 weeks’ gestational age. The cases were followed up until xiii delivery to detect those with severe disease as evidenced by adverse pregnancy outcome. The data obtained was imputed into an SPSS computer statistical software version 22 (IBM SPSS statistics for windows version 22.0.Armonk, NY IBM Corp) and was analysed using the same software. A P-value of less than 0.05 was considered statistically significant.