This study aims at comparing the clinical efficacy of Ceftriaxone and Ampiclox, Gentamicin and Metronidazole in decreasing the frequency of post-caesarean section infection related morbidity. Two hundred Patients planned for caesarean section for various indications (e.g. breech presentation, two previous caesarean sections placenta praevia e.t.c) and who satisfied the inclusion criteria were randomly given either ceftriaxone (single dose) or a combination of ampliclox, gentamicin and metronidazole after clamping of the cord and for seven days thereafter. All participants were examined to screen for infection and had a midstream or catheter specimen of urine collected for microscopy, culture and sensitivity before surgery and on postoperative days 3 and 5, an endocervical and wound swabs for microscopy culture and sensitivity were also collected on postoperative days 3 and 5. Those who developed febrile morbidity were examined to localize the potential source of infection (wound, tonsils, breasts, chest, abdomen and pelvis), total white blood cells count and differentials, as well as blood was sent for culture and sensitivity testing. Blood films (thick and thin) were also taken and stained for malaria parasite. Participants who developed endometritis, wound infection, urinary tract infection were treated based on the organism grown on culture and its antibiotic sensitivity pattern. The mean age, parity, gestational age and packed cell volume were similar in the two groups. There was no significant statistical difference in the incidence of febrile morbidity ( p = 0.774 ), endometritis ( p = 0.841 ), wound infection ( p = 0.788 ), urinary tract infection ( p = 0.400 ) and mean duration of hospital stay ( p = 0.412 ). The mean cost of antibiotic treatment in the ceftriaxone group was 1202.50Naira and 1980.53Naira for the combination of Ampiclox, Gentamicin and Metronidazole and this was statistically significant ( p = 0.000). A single dose of Ceftriaxone was as effective as a combination of Ampiclox, Gentamicin and Metronidazole in preventing post caesarean section infectious complications and is cheaper and easier to administer.