Background: Chronic liver disease (CLD) is a major public health problem which accounts for significant morbidity and mortality figures worldwide most especially in developing countries where hepatitis B virus is also endemic. The aetiology of CLD is protean and also diverse depending on the region being studied. Current epidemiological data reveals that in Africa and other developing countries, hepatitis B viral (HBV) infection is the most common cause of chronic liver disease, while alcohol followed by hepatitis C virus (HCV) are significant causes of chronic liver disease in developed countries of Europe and U.S.A. Non-alcoholic fatty liver disease (NAFLD) in addition plays a major role in the aetiology of CLD particularly in areas where obesity and diabetes mellitus is a growing public health challenge . Aims and Objectives: The main aim of this study was to determine the prevalence of chronic liver disease and its common aetiologic agents (hepatitis B, hepatitis C, alcoholic liver disease, non-alcoholic liver disease), in addition to its risk factors in Calabar, Cross River, State. Methods: This study was an observational cross-sectional case control study involving patients with suspected chronic liver disease referred to the Gastroenterology clinic or admitted into the medical wards and subsequently referred to the Gastroenterology unit 2 of the University of Calabar teaching hospital. Two hundred and thirteen individuals were recruited ( over a nine month period from September 2012 to May 2013) for the study comprising 106 patients with clinical, biochemical , ultrasonographic and histologic features of chronic liver disease and 107 personnel of UCTH and non-liver disease patients as controls. The controls were matched with the cases according to age and sex.