Hypoxic ischaemic encephalopathy preceded by perinatal hypoxic-ischaemic insult is a major contributor to global child morbidity and mortality. The adaptive circulatory responses following an episode of ischaemia/hypoxia may lead to decreased renal perfusion and ultimately renal injury. Neonates who survive a transient episode of acute kidney injury (AKI) are at increased risk for long term chronic kidney disease (CKD). Objectives; To determine the prevalence of acute kidney injury among term neonates with Hypoxic Ischaemic Encephalopathy (HIE) in FMC, Umuahia and to ascertain if there is a relationship between degree of hypoxic ischaemic encephalopathy and Acute Kidney Injury (AKI) incidence and severity. Methods; This was a hospital based cross-sectional study carried out between 6th of November 2019 and 5th of September 2020. Neonates who met the inclusion criteria were consecutively enrolled at presentation within 24hours of delivery. Hypoxic ischaemic encephalopathy (HIE) was defined and staged using the Thompson’s score while AKI was defined and graded using the modified neonatal KDIGO criteria. Socio-demographic and clinical data of mothers and babies were obtained via a proforma designed for the study. Statistical analysis was done using the IBM SPSS statistics software version 20. The relationship between HIE and the prevalence of AKI was tested using chi-square while the strength of association between the stages of HIE and the presence of AKI was tested using logistic regression. Probability value of <0.05 was considered statistically significant.