Background: Preeclampsia is reported to complicate 2-8% of pregnancies globally and is an important cause of maternal and perinatal morbidity and mortality.4, 5Despite extensive research into the subject area, the aetiology and pathogenesis is still poorly understood and substantial improvement has not been made in the prediction, prevention and treatment of the disease. The study was designed to compare the frequency of activated protein C resistance (APC-R) in patients with pre-eclampsia to that of normotensive pregnant women and to determine the correlation of activated protein ratio (APC-ratio) and the severity of pre-eclampsia. Methods: A cross sectional study was carried out in 100 pre-eclampsia patients and 100 normotensive pregnant controls. The APC-ratio was determined using the modified activated partial thromboplastin time. Study participants with APC-ratio of less than 2.0 were defined as having APC-R. Data was analyzed using SPSS version 22.0.