Background: Malaria in pregnancy continues to be a major public health problem in sub-Saharan Africa. Pregnant women being a specific at risk group for placental malaria infection especially with Plasmodium falciparum infection and related consequences. Placental sequestration of parasitized erythrocytes, jeopardize the functions of the placenta with adverse foetal outcome. These outcomes include preterm delivery, low birth weight, stillbirth, congenital malaria, congenital anaemia and low placental weight. Peripheral blood film microscopy grossly underestimates the prevalence of this placental malaria. The use of sulphadoxine-pyrimathamine recommended by the WHO for intermittent preventive therapy expected to reduce placental malaria rate and improved foetal outcome. OBJECTIVE: To determine the influence of placental malaria on the foetal outcome STUDY DESIGN: A hospital based cross-sectional study. METHODOLGY: During February-July, 2014, 477 singleton mothernewborn pairs consecutively recruited into the study.Maternal blood, placental blood and tissues specimens were collected at delivery and analyzed accordingly. Babies were clinically assessed immediately after delivery and placental weight.