Background The aim of this study was to analyse the clinicopathological profile of tumours of the eyes and ocular adnexa in Ibadan, Nigeria. Materials and methods The slides and tissue blocks of tumours of eye and ocular adnexa diagnosed in the Department of Pathology, UCH, Ibadan, Nigeria from January 1, 2003 to December 31, 2012 were retrieved. Slides were reviewed and where blocks were retrievable from archives appropriate histochemical and immunohistochemical panels were applied for confirmation of definitive diagnosis and for disease sub classification. The data obtained was analysed, employing the student’s t test for continuous variables and the chi squared test for discontinuous variables, with the level of statistical significance set at p ≤ 0.05.