Background Peripheral lymphadenopathy remains an extremely common clinical presentation in Nigeria, and there have been many studies published on it from different parts of the country. The last study in University College Hospital, Ibadan was in 1995. The aim of the current study is to provide an update of the clinicopathological pattern of lymphadenopathy in Ibadan. Methodology All cases of lymph node biopsies received at the Department of Pathology, University College Hospital, Ibadan, Nigeria from January 1st 2003 to December 31st 2012 were reviewed. The clinical data, slides and paraffin blocks of these cases were retrieved. Fresh sections were prepared and stained with haematoxylin and eosin. Special stains and immunohistochemistry were also applied. The data was analysed using the student’s t and F tests for continuous variables and the chi-squared test for discontinuous variables, with level of significance being p ≤ 0.05.